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Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways

Hypothalamic obesity (HO) is a disabling disease caused by central nervous system (CNS) damage due to neurosurgery, trauma, or tumors, especially in hypothalamus. The pathological mechanism of its neural circuits is still unclear, and there is currently no corresponding drug due to the complex etiol...

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Hoofdauteurs: Junjie Peng, Yichao Ou, Mingfeng Zhou, Xingqin Wang, Xi’an Zhang, Hao Long, Guangsen Wu, Mengjie Che, Kai Li, Le Yang, Zhu Zhang, Ken Kin Lam Yung, Songtao Qi, Zhanpeng Feng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2026-01-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
CaMKK2/AMPK signaling
GPCRs
hypothalamic obesity
melanocortin 4 receptor
neuropharmacology
setmelanotide
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1730786/full
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