Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways

Hypothalamic obesity (HO) is a disabling disease caused by central nervous system (CNS) damage due to neurosurgery, trauma, or tumors, especially in hypothalamus. The pathological mechanism of its neural circuits is still unclear, and there is currently no corresponding drug due to the complex etiol...

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Main Authors:	Junjie Peng, Yichao Ou, Mingfeng Zhou, Xingqin Wang, Xi’an Zhang, Hao Long, Guangsen Wu, Mengjie Che, Kai Li, Le Yang, Zhu Zhang, Ken Kin Lam Yung, Songtao Qi, Zhanpeng Feng
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-01-01
Series:	Frontiers in Pharmacology
Subjects:	CaMKK2/AMPK signaling GPCRs hypothalamic obesity melanocortin 4 receptor neuropharmacology setmelanotide
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1730786/full
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