Mechanism of increased efficacy of recombinant Fc‐μTP‐L309C compared to IVIg to ameliorate mouse immune thrombocytopenia

Abstract Recombinant Fc‐μTP‐L309C is more efficacious than intravenous immunoglobulin (IVIg) at ameliorating antibody‐mediated autoimmune diseases through its effects on Fcγ receptors (FcγRs). Fc‐μTP‐L309C inhibited in‐vitro FcγR‐mediated phagocytosis 104/105‐fold better than IVIg. Fc‐μTP‐L309C, giv...

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Autori principali:	Bonnie J.B. Lewis, Beth Binnington, Megan Blacquiere, Rolf Spirig, Fabian Käsermann, Donald R. Branch
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2021-11-01
Serie:	eJHaem
Soggetti:	immune thrombocytopenia immunotherapy ITP ITP intravenous immunoglobulin IVIG IVIg
Accesso online:	https://doi.org/10.1002/jha2.304
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