Mechanism of increased efficacy of recombinant Fc‐μTP‐L309C compared to IVIg to ameliorate mouse immune thrombocytopenia

Abstract Recombinant Fc‐μTP‐L309C is more efficacious than intravenous immunoglobulin (IVIg) at ameliorating antibody‐mediated autoimmune diseases through its effects on Fcγ receptors (FcγRs). Fc‐μTP‐L309C inhibited in‐vitro FcγR‐mediated phagocytosis 104/105‐fold better than IVIg. Fc‐μTP‐L309C, giv...

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Bibliografische gegevens

Hoofdauteurs:	Bonnie J.B. Lewis, Beth Binnington, Megan Blacquiere, Rolf Spirig, Fabian Käsermann, Donald R. Branch
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2021-11-01
Reeks:	eJHaem
Onderwerpen:	immune thrombocytopenia immunotherapy ITP ITP intravenous immunoglobulin IVIG IVIg
Online toegang:	https://doi.org/10.1002/jha2.304
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