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Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin lesions and more severe allergen-induced dermatitis than wild-type mice. Mast cells were required for both AD models and remarkably increase...

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Váldodahkkit: Tomoaki Ando, Wenbin Xiao, Peisong Gao, Siavash Namiranian, Kenji Matsumoto, Yoshiaki Tomimori, Hong Hong, Hirotaka Yamashita, Miho Kimura, Jun-ichi Kashiwakura, Tissa R. Hata, Kenji Izuhara, Michael F. Gurish, Axel Roers, Nicholas M. Rafaels, Kathleen C. Barnes, Colin Jamora, Yuko Kawakami, Toshiaki Kawakami
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2014-01-01
Ráidu:Cell Reports
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2211124713007870
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