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Protein kinase function of pyruvate kinase M2 and cancer

Abstract Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and...

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Bibliographic Details
Main Authors: Xun Chen, Shangwu Chen, Dongsheng Yu
Format: Artigo
Language:Inglês
Published: BMC 2020-10-01
Series:Cancer Cell International
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12935-020-01612-1
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