African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

Abstract Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide association studies of six iron-related biomarkers in 3928 children from five sites across Africa, with replication in 2868 African American a...

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Principais autores:	John Muthii Muriuki, Alexander J. Mentzer, Gavin Band, Amanda Y. Chong, Alex W. Macharia, Reagan M. Mogire, Kelvin Mokaya Abuga, Ruth Mitchell, James J. Gilchrist, Emily L. Webb, Francis M. Ndungu, Laura M. Raffield, Lynette Ekunwe, Amy R. Bentley, Sodiomon B. Sirima, Shabir A. Madhi, Adrian V. S. Hill, Andrew M. Prentice, Philip Bejon, Gibran Hemani, George Davey Smith, Manjinder S. Sandhu, Alison M. Elliott, Thomas N. Williams, Adebowale Adeyemo, Sarah H. Atkinson
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-04-01
Serija:	Nature Communications
Online dostop:	https://doi.org/10.1038/s41467-026-71567-w
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