African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children

Abstract Iron is essential for both humans and pathogens, yet its genetic regulation remains understudied in African populations. Here, we report genome-wide association studies of six iron-related biomarkers in 3928 children from five sites across Africa, with replication in 2868 African American a...

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Egile Nagusiak:	John Muthii Muriuki, Alexander J. Mentzer, Gavin Band, Amanda Y. Chong, Alex W. Macharia, Reagan M. Mogire, Kelvin Mokaya Abuga, Ruth Mitchell, James J. Gilchrist, Emily L. Webb, Francis M. Ndungu, Laura M. Raffield, Lynette Ekunwe, Amy R. Bentley, Sodiomon B. Sirima, Shabir A. Madhi, Adrian V. S. Hill, Andrew M. Prentice, Philip Bejon, Gibran Hemani, George Davey Smith, Manjinder S. Sandhu, Alison M. Elliott, Thomas N. Williams, Adebowale Adeyemo, Sarah H. Atkinson
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2026-04-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-026-71567-w
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