A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
Genetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers that drive the expression of PRDM6 and are partly regulated by STAT1 as the caus...
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| Huvudupphov: | , , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
American Society for Clinical Investigation
2023-03-01
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| Serie: | The Journal of Clinical Investigation |
| Ämnen: | |
| Länkar: | https://doi.org/10.1172/JCI160036 |
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