A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension

Genetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers that drive the expression of PRDM6 and are partly regulated by STAT1 as the caus...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Kushan L. Gunawardhana, Lingjuan Hong, Trojan Rugira, Severin Uebbing, Joanna Kucharczak, Sameet Mehta, Dineth R. Karunamuni, Brenda Cabera-Mendoza, Neeru Gandotra, Curt Scharfe, Renato Polimanti, James P. Noonan, Arya Mani
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Society for Clinical Investigation 2023-03-01
Цуврал:	The Journal of Clinical Investigation
Нөхцлүүд:	Cardiology Nephrology
Онлайн хандалт:	https://doi.org/10.1172/JCI160036
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!