Obakulactone Alleviates Rheumatoid Arthritis by Promotion of ACOT1 Degradation via the Ubiquitin‒Proteasome Pathway and Restoration of Unsaturated Fatty Acid Homeostasis

Rheumatoid arthritis (RA) remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments. Obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, has emerged as a promising candidate for RA intervention. Howev...

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Detaylı Bibliyografya

Asıl Yazarlar:	Hongda Liu, Le Yang, Yu Yang, Huan Tang, Junling Ren, Hui Sun, Xin Sun, Songyuan Tang, Chong Qiu, Ye Sun, Jigang Wang, Guangli Yan, Ling Kong, Ying Han, Xijun Wang
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Elsevier 2026-01-01
Seri Bilgileri:	Engineering
Konular:	Obakulactone Rheumatoid arthritis Unsaturated fatty acids Acyl coenzyme A thioesterase 1 Synovial fibroblasts Multiomics
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S2095809925006678
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