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Obakulactone Alleviates Rheumatoid Arthritis by Promotion of ACOT1 Degradation via the Ubiquitin‒Proteasome Pathway and Restoration of Unsaturated Fatty Acid Homeostasis

Rheumatoid arthritis (RA) remains a therapeutic challenge because of the suboptimal efficacy and significant adverse effects of current treatments. Obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, has emerged as a promising candidate for RA intervention. Howev...

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Principais autores: Hongda Liu, Le Yang, Yu Yang, Huan Tang, Junling Ren, Hui Sun, Xin Sun, Songyuan Tang, Chong Qiu, Ye Sun, Jigang Wang, Guangli Yan, Ling Kong, Ying Han, Xijun Wang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-01-01
Serier:Engineering
Fag:
Obakulactone
Rheumatoid arthritis
Unsaturated fatty acids
Acyl coenzyme A thioesterase 1
Synovial fibroblasts
Multiomics
Online adgang:http://www.sciencedirect.com/science/article/pii/S2095809925006678
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