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Reactive pericytes in early phase are involved in glial activation and late-onset hypersusceptibility to pilocarpine-induced seizures in traumatic brain injury model mice

In this study, among neurovascular unit (NVU) cells, we focused on pericyte reactivity in mice subjected to controlled cortical impact (CCI) to understand how traumatic brain injury (TBI) causes uncoordinated crosstalk in the NVU and alters neuronal activity. Histological analyses of brain pericytes...

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Principais autores: Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohgu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021-01-01
coleção:Journal of Pharmacological Sciences
Assuntos:
Traumatic brain injury
Reactive pericytes
PDGFRβ
Imatinib
Microglia
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1347861320301146
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