Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis.
The paper describes a mathematical model of the molecular switches of cell survival, apoptosis, and necroptosis in cellular signaling pathways initiated by tumor necrosis factor 1. Based on experimental findings in the literature, we constructed a Petri net model based on detailed molecular reaction...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science (PLoS)
2022-08-01
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| Seria: | PLoS Computational Biology |
| Dostęp online: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010383&type=printable |
| Etykiety: |
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