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Synthesis, In Vivo Anticonvulsant Activity Evaluation and In Silico Studies of Some Quinazolin-4(3H)-One Derivatives

Two series, “<b>a</b>” and “<b>b</b>”, each consisting of nine chemical compounds, with 2,3-disubstituted quinazolin-4(3H)-one scaffold, were synthesized and evaluated for their anticonvulsant activity. They were investigated as dual potential positive allosteric modulators of the GABA<sub>A</sub> r...

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Principais autores: Raluca Pele, Gabriel Marc, Cristina Mogoșan, Anamaria Apan, Ioana Ionuț, Brîndușa Tiperciuc, Cristina Moldovan, Cătălin Araniciu, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase, Ovidiu Oniga
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-04-01
Serier:Molecules
Fag:
quinazolin-4(3H)-one
anticonvulsant activity
molecular docking
molecular dynamics
Online adgang:https://www.mdpi.com/1420-3049/29/9/1951
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