New Quinazolin-4(3<i>H</i>)-one Derivatives as Potential Antitumoral Compounds: Synthesis, In Vitro Cytotoxicity Against the HepG2 Cell Line, and In Silico VEGFR-2 Targeting-Based Studies

Three new 2,3-disubstituted quinazolin-4(3<i>H</i>)-one derivatives (<b>5a</b>–<b>c</b>) were synthesized by the nucleophilic <i>S</i>-alkylation of 2-mercaptoquinazolin-4(3<i>H</i>)-one derivatives (<b>3a</b>–<b>c</b>) with 5-(2-bromoacetyl)-2-hydroxybenzamide (<b>4</b>) in alkaline conditions. The...

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Váldodahkkit:	Raluca Pele, Gabriel Marc, Brîndușa Tiperciuc, Ioana Ionuț, Anca Stana, Cristina Moldovan, Corina Tatomir, Oana Maria Dragostin, Adrian Pîrnău, Laurian Vlase, Daniel Ungureanu, Ovidiu Oniga
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2025-12-01
Ráidu:	Molecules
Fáttát:	quinazolin-4(<i>3H</i>)-one HepG2 cell line sorafenib molecular docking VEGFR-2
Liŋkkat:	https://www.mdpi.com/1420-3049/30/24/4719
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