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Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver

The function and regulation of amyloid-beta (Aβ) in healthy and diseased liver remains unexplored. Because Aβ reduces the integrity of the blood-brain barrier we have examined its potential role in regulating the sinusoidal permeability of normal and cirrhotic liver. Aβ and key protei...

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Autors principals: Gayane Hrachia Buniatian, Ralf Weiskirchen, Thomas S. Weiss, Ute Schwinghammer, Martin Fritz, Torgom Seferyan, Barbara Proksch, Michael Glaser, Ali Lourhmati, Marine Buadze, Erawan Borkham-Kamphorst, Frank Gaunitz, Christoph H. Gleiter, Thomas Lang, Elke Schaeffeler, Roman Tremmel, Holger Cynis, William H. Frey, Rolf Gebhardt, Scott L. Friedman, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2020-02-01
Col·lecció:Cells
Matèries:
liver cirrhosis
liver sinusoidal permeability
liver sinusoidal endothelial cells
hepatic stellate cells
beta secretase
presenilin
endothelial nitric oxide synthase
myelin basic protein
alzheimer’s disease
neprilysin
astrocytes
Accés en línia:https://www.mdpi.com/2073-4409/9/2/452
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