ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth

Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic translocation. Although CIC is known to be inactivated by phosphorylation, the mechanisms underlying the cytoplasmic transl...

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Váldodahkkit:	Jongmin Park, Guk-Yeol Park, Jongeun Lee, Joonyoung Park, Soeun Kim, Eunjeong Kim, Seung-Yeol Park, Jong Hyuk Yoon, Yoontae Lee
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2022-12-01
Ráidu:	Frontiers in Molecular Biosciences
Fáttát:	CIC ERK receptor tyrosine kinase cytoplasmic translocation tumor suppressor
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1030725/full
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