RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

Abstract Background Myeloid epithelial reproductive tyrosine kinase (MERTK) receptor is overexpressed in cancers and is associated with poor prognosis. RGX-019-MMAE, a novel humanized IgG1-MMAE antibody-drug conjugate (ADC) (Inspirna, Inc), selectively binds to MERTK with high affinity, resulting in...

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主要な著者:	Anudishi Tyagi, Maryam Siddiqui, Amanda Eckstrom, Isabel Kurth, Shugaku Takeda, Priyanka Sharma, Gautam Borthakur, Bin Yuan, Hussein A. Abbas, Vivek Anand, Jenny Borgman, Steven Kornblau, Abhishek Maiti, V. Lokesh Battula
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2026-03-01
シリーズ:	Journal of Experimental & Clinical Cancer Research
主題:	Myeloid epithelial tyrosine kinase (MERTK) Antibody drug conjugate (ADC) Monomethyl auristatin e (MMAE) Reverse phase protein arrays (RPPA) Acute myeloid leukemia (AML)
オンライン･アクセス:	https://doi.org/10.1186/s13046-026-03657-y
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