RGX-019-MMAE inhibits leukemia progression by targeting MER proto-oncogene tyrosine kinase (MERTK) in acute myeloid leukemia

Abstract Background Myeloid epithelial reproductive tyrosine kinase (MERTK) receptor is overexpressed in cancers and is associated with poor prognosis. RGX-019-MMAE, a novel humanized IgG1-MMAE antibody-drug conjugate (ADC) (Inspirna, Inc), selectively binds to MERTK with high affinity, resulting in...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Anudishi Tyagi, Maryam Siddiqui, Amanda Eckstrom, Isabel Kurth, Shugaku Takeda, Priyanka Sharma, Gautam Borthakur, Bin Yuan, Hussein A. Abbas, Vivek Anand, Jenny Borgman, Steven Kornblau, Abhishek Maiti, V. Lokesh Battula
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2026-03-01
Rangatū:	Journal of Experimental & Clinical Cancer Research
Ngā marau:	Myeloid epithelial tyrosine kinase (MERTK) Antibody drug conjugate (ADC) Monomethyl auristatin e (MMAE) Reverse phase protein arrays (RPPA) Acute myeloid leukemia (AML)
Urunga tuihono:	https://doi.org/10.1186/s13046-026-03657-y
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!