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Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

Mammalian cochlear outer hair cells (OHCs) are essential for hearing. Severe hearing impairment follows OHC degeneration. Previous attempts at regenerating new OHCs from cochlear supporting cells (SCs) have been unsuccessful, notably lacking expression of the key OHC motor protein, Prestin. Thus, re...

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Principais autores: Suhong Sun, Shuting Li, Zhengnan Luo, Minhui Ren, Shunji He, Guangqin Wang, Zhiyong Liu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2021-09-01
coleção:eLife
Assuntos:
prestin
outer hair cell
cochlea
Ikzf2
Atoh1
regeneration
Acesso em linha:https://elifesciences.org/articles/66547
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