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Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids

Summary: Human pluripotent stem cell-derived cochlear organoids are promising tools for studying human cochlear development and disease. However, the maturation of hair cells in these organoids is slow, requiring 200 days to express the mature outer hair cell marker Prestin. To promote hair cell mat...

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主要な著者: Tsubasa Saeki, Yoshitomo Ueda, Isabel Aristizábal-Ramírez, Stephen T. Moore, Rick F. Nelson, Gregory I. Frolenkov, Eri Hashino
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2026-02-01
シリーズ:Cell Reports
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オンライン・アクセス:http://www.sciencedirect.com/science/article/pii/S2211124725016705
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