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The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and differentiation. Here we characterize the role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex. Ddb1 is highly expressed in multipotent hematopoietic progenitors and its deletion leads...

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Principais autores: Jie Gao, Shannon M Buckley, Luisa Cimmino, Maria Guillamot, Alexandros Strikoudis, Yong Cang, Stephen P Goff, Iannis Aifantis
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2015-11-01
Serier:eLife
Fag:
stem cell
ubiquitin proteasome system
hematopoiesis
embryonic stem cell
Online adgang:https://elifesciences.org/articles/07539
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