Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma

The cullin-based CRL4-CDT2 ubiquitin ligase is emerging as a master regulator of cell proliferation. CRL4-CDT2 prevents re-initiation of DNA replication during the same cell cycle “rereplication” through targeted degradation of CDT1, SET8 and p21 during S-phase of the cell cycle. We show that CDT2 i...

Descripción completa

Detalles Bibliográficos

Autores principales:	Mouadh Benamar, Fadila Guessous, Kangping Du, Patrick Corbett, Joseph Obeid, Daniel Gioeli, Craig L. Slingluff Jr, Tarek Abbas
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2016-08-01
Colección:	EBioMedicine
Materias:	Melanoma CDT2 DTL Cullin Ubiquitylation MLN4924 Pevonedistat BRAF NRAS
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2352396416302791
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!