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Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings

Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, short‐circuit current, and transepithelial resistance c...

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Autors principals: Preston E. Bratcher, Sangya Yadav, Ciaran A. Shaughnessy, Ian M. Thornell, Pamela L. Zeitlin
Format: Artigo
Idioma:Inglês
Publicat: Wiley 2020-10-01
Col·lecció:Physiological Reports
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Accés en línia:https://doi.org/10.14814/phy2.14603
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