Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings

Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, short‐circuit current, and transepithelial resistance c...

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Bibliografische gegevens

Hoofdauteurs:	Preston E. Bratcher, Sangya Yadav, Ciaran A. Shaughnessy, Ian M. Thornell, Pamela L. Zeitlin
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Wiley 2020-10-01
Reeks:	Physiological Reports
Onderwerpen:	CFTR modulator chloride gradient Cystic fibrosis in vitro efficacy
Online toegang:	https://doi.org/10.14814/phy2.14603
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