In vivo Overexpression of Electrogenic Sodium/Bicarbonate Cotransporter (NBCe1) by AAV9 Modifies the Cardiac Action Potential and the QT Interval in Mice

Cardiac cells depend on specific sarcolemmal ion transporters to assure the correct intracellular pH regulation. The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms. In the heart two different NBC isoforms have been described: the electroneutral NBCn1 (1Na+:1HCO3-)...

Volledige beschrijving

Bibliografische gegevens

Hoofdauteurs:	Romina A. Di Mattía, Leandro A. Díaz Zegarra, Carlos A. Valverde, Paula G. Blanco, Carolina Jaquenod De Giusti, Enrique L. Portiansky, Ernesto A. Aiello, Alejandro Orlowski
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2022-04-01
Reeks:	Frontiers in Cardiovascular Medicine
Onderwerpen:	NBCe1 adeno-associated virus (AAV) ECG action potential mice
Online toegang:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.862118/full
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!