In vivo Overexpression of Electrogenic Sodium/Bicarbonate Cotransporter (NBCe1) by AAV9 Modifies the Cardiac Action Potential and the QT Interval in Mice

Cardiac cells depend on specific sarcolemmal ion transporters to assure the correct intracellular pH regulation. The sodium/bicarbonate cotransporter (NBC) is one of the major alkalinizing mechanisms. In the heart two different NBC isoforms have been described: the electroneutral NBCn1 (1Na+:1HCO3-)...

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Bibliografske podrobnosti

Principais autores:	Romina A. Di Mattía, Leandro A. Díaz Zegarra, Carlos A. Valverde, Paula G. Blanco, Carolina Jaquenod De Giusti, Enrique L. Portiansky, Ernesto A. Aiello, Alejandro Orlowski
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-04-01
Serija:	Frontiers in Cardiovascular Medicine
Teme:	NBCe1 adeno-associated virus (AAV) ECG action potential mice
Online dostop:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.862118/full
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