Non-suppressible HIV viremia sustained by clonally expanded CD4+ T cells harboring a genomically defective provirus with an immune-evasive protein expression profile

ABSTRACT Antiretroviral therapy (ART) potently inhibits HIV replication but does not eliminate HIV proviruses integrated within the genomes of infected cells. Though ART normally suppresses HIV to clinically undetectable levels in blood, some individuals experience non-suppressible viremia (NSV) tha...

Descrizione completa

Dettagli Bibliografici

Autori principali:	F. Harrison Omondi, Yurou Sang, Winnie Dong, Francis Mwimanzi, Peter K. Cheung, Evan Barad, Zerufael Derza, Kieran Anderson, Aniqa Shahid, Vitaliy Mysak, Viviane D. Lima, Mark Hull, Chanson J. Brumme, Marianne Harris, Julio S. G. Montaner, Silvia Guillemi, Mark A. Brockman, Zabrina L. Brumme
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2026-05-01
Serie:	mBio
Soggetti:	human immunodeficiency virus (HIV) non-suppressible viremia non-subtype B HIV alternative splicing clonally expanded provirus major splice donor (MSD) site
Accesso online:	https://journals.asm.org/doi/10.1128/mbio.03909-25
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!