Non-suppressible HIV viremia sustained by clonally expanded CD4+ T cells harboring a genomically defective provirus with an immune-evasive protein expression profile

ABSTRACT Antiretroviral therapy (ART) potently inhibits HIV replication but does not eliminate HIV proviruses integrated within the genomes of infected cells. Though ART normally suppresses HIV to clinically undetectable levels in blood, some individuals experience non-suppressible viremia (NSV) tha...

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Hlavní autoři:	F. Harrison Omondi, Yurou Sang, Winnie Dong, Francis Mwimanzi, Peter K. Cheung, Evan Barad, Zerufael Derza, Kieran Anderson, Aniqa Shahid, Vitaliy Mysak, Viviane D. Lima, Mark Hull, Chanson J. Brumme, Marianne Harris, Julio S. G. Montaner, Silvia Guillemi, Mark A. Brockman, Zabrina L. Brumme
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2026-05-01
Edice:	mBio
Témata:	human immunodeficiency virus (HIV) non-suppressible viremia non-subtype B HIV alternative splicing clonally expanded provirus major splice donor (MSD) site
On-line přístup:	https://journals.asm.org/doi/10.1128/mbio.03909-25
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