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PE/PPE proteins contribute to Mycobacterium tuberculosis drug resistance

Abstract The mycobacterial outer membrane (OM) creates a formidable permeability barrier, and whether drugs traverse it by mechanisms other than passive diffusion remains unclear. The proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) proteins of pathogenic mycobacteria include sever...

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Autori principali: Vishant Boradia, Junxi Chen, Andrew Frando, Lindsay V. Clark, Christoph Grundner
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-04-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-026-72431-7
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