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Ongoing evolution of PE/PPE genes in Mycobacterium tuberculosis associated with drug resistance and host immune response

ABSTRACT The Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) gene family comprises approximately 10% of the Mycobacterium tuberculosis (Mtb) genome and is characterized by GC-rich, highly repetitive sequences. As a result, these genes are usually excluded from short-read-based whole-genome sequ...

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Principais autores: Mingyu Gan, Dan Wang, Suqing Li, Qinglan Wang, Qingyun Liu
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2025-10-01
Series:mSystems
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Acceso en liña:https://journals.asm.org/doi/10.1128/msystems.00898-25
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