The alphaherpesvirus gE/gI glycoprotein complex and proteases jointly orchestrate invasion across the host’s upper respiratory epithelial barrier

ABSTRACT Alphaherpesviruses, including herpes simplex virus type 1 (HSV-1), pseudorabies virus (PRV), and bovine herpesvirus type 1 (BoHV-1), are significant pathogens affecting humans and animals. These viruses penetrate the upper respiratory tract mucosa, yet the mechanisms facilitating this invas...

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Ngā kaituhi matua:	E. Van Crombrugge, X. Ren, S. Glorieux, I. Zarak, W. Van den Broeck, C. Bachert, N. Zhang, T. Van Zele, D. Kim, G. A. Smith, K. Laval, H. Nauwynck
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	American Society for Microbiology 2024-11-01
Rangatū:	mBio
Ngā marau:	alphaherpesvirus upper respiratory tract pathogenesis, mucosa invasion gE/gI complex proteases urokinase plasminogen activator
Urunga tuihono:	https://journals.asm.org/doi/10.1128/mbio.01873-24
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