EP9158H: An Immunoinformatics-Designed mRNA Vaccine Encoding Multi-Epitope Antigens and Dual TLR Agonists for Tuberculosis Prevention

<b>Background</b>: Tuberculosis (TB) remains a pressing global health crisis. The inadequate efficacy of the BCG vaccine against adult pulmonary TB underscores the urgent need for novel, effective vaccines. This study aimed to design a novel mRNA vaccine candidate against TB using a rational immunoi...

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Autori principali:	Mingming Zhang, Syed Luqman Ali, Yuan Tian, Aigul Abduldayeva, Shuang Zhou, Yajing An, Yufeng Li, Ruizi Ni, Lingxia Zhang, Yanhua Liu, Weiguo Sun, Wenping Gong
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2025-12-01
Serie:	Bioengineering
Soggetti:	tuberculosis mRNA vaccine immunoinformatics TLR agonist molecular dynamics immune simulation
Accesso online:	https://www.mdpi.com/2306-5354/12/12/1378
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