(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis

The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions – (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP. Although transcription of mutant repeats into (CUG)DM1...

全面介绍

书目详细资料

Principais autores:	Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma García-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo López Castel, Ralf Krahe, Andreas Bergmann
格式:	Artigo
语言:	Inglês
出版:	The Company of Biologists 2017-08-01
丛编:	Disease Models & Mechanisms
主题:	Myotonic dystrophy DM2 RNA toxicity Drosophila Muscleblind Apoptosis
在线阅读:	http://dmm.biologists.org/content/10/8/993
标签:	添加标签 没有标签, 成为第一个标记此记录!