Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.

The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of aldehyde dehydrogenases has been implicated in neurologic disorder and cancer in humans. However, cellular respon...

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Главные авторы:	Lidan Zeng, Xuesong Li, Christopher B Preusch, Gary J He, Ningyi Xu, Tom H Cheung, Jianan Qu, Ho Yi Mak
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2021-07-01
Серии:	PLoS Genetics
Online-ссылка:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009635&type=printable
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