cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
Direct regulation of the pacemaker “funny” current (If) by cyclic AMP (cAMP) underlies heart rate modulation by the autonomic nervous system. At the molecular level, cAMP activates hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that drive If in sinoatrial node (SAN) myocytes. Eve...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020-07-01
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| coleção: | Frontiers in Physiology |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/article/10.3389/fphys.2020.00771/full |
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