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BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses

Given the lack of treatments for diabetic neuropathy (DN), a common diabetic complication, accurate disease models are necessary. Characterization of the leptin-deficient BTBR ob/ob mouse, a type 2 diabetes model, demonstrated that the mice develop robust diabetes coincident with severe neuropathic...

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Principais autores: Phillipe D. O'Brien, Junguk Hur, John M. Hayes, Carey Backus, Stacey A. Sakowski, Eva L. Feldman
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-01-01
Serier:Neurobiology of Disease
Fag:
Type-2 diabetes
Obesity
Diabetic neuropathy
Mouse model
Leptin
Gene expression analysis
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996114003283
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