BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses

Given the lack of treatments for diabetic neuropathy (DN), a common diabetic complication, accurate disease models are necessary. Characterization of the leptin-deficient BTBR ob/ob mouse, a type 2 diabetes model, demonstrated that the mice develop robust diabetes coincident with severe neuropathic...

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Autors principals:	Phillipe D. O'Brien, Junguk Hur, John M. Hayes, Carey Backus, Stacey A. Sakowski, Eva L. Feldman
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2015-01-01
Col·lecció:	Neurobiology of Disease
Matèries:	Type-2 diabetes Obesity Diabetic neuropathy Mouse model Leptin Gene expression analysis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S0969996114003283
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