Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Summary: Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α [E...

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Үндсэн зохиолчид:	Zhenqi Zhou, Timothy M. Moore, Alexander R. Strumwasser, Vicent Ribas, Hirotaka Iwasaki, Noelle Morrow, Alice Ma, Peter H. Tran, Jonathan Wanagat, Thomas Q. de Aguiar Vallim, Bethan Clifford, Zhengyi Zhang, Tamer Sallam, Brian W. Parks, Karen Reue, Orian Shirihai, Rebeca Acin-Perez, Marco Morselli, Matteo Pellegrini, Sushil K. Mahata, Frode Norheim, Mingqi Zhou, Marcus M. Seldin, Aldons J. Lusis, Cathy C. Lee, Mark O. Goodarzi, Jerome I. Rotter, Joshua R. Hansen, Ben Drucker, Tyler J. Sagendorf, Joshua N. Adkins, James A. Sanford, Francesco J. DeMayo, Sylvia C. Hewitt, Kenneth S. Korach, Andrea L. Hevener
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-05-01
Цуврал:	Cell Reports Medicine
Нөхцлүүд:	estrogen action insulin sensitivity mitochondrial function mtDNA replication mitochondrial cristae architecture oxidative metabolism
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2666379125001892
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!