Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males

Summary: Reduced estrogen action is associated with obesity and insulin resistance. However, the cell and tissue-specific actions of estradiol in maintaining metabolic health remain inadequately understood, especially in men. We observed that skeletal muscle ESR1/Esr1 (encodes estrogen receptor α [E...

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Principais autores:	Zhenqi Zhou, Timothy M. Moore, Alexander R. Strumwasser, Vicent Ribas, Hirotaka Iwasaki, Noelle Morrow, Alice Ma, Peter H. Tran, Jonathan Wanagat, Thomas Q. de Aguiar Vallim, Bethan Clifford, Zhengyi Zhang, Tamer Sallam, Brian W. Parks, Karen Reue, Orian Shirihai, Rebeca Acin-Perez, Marco Morselli, Matteo Pellegrini, Sushil K. Mahata, Frode Norheim, Mingqi Zhou, Marcus M. Seldin, Aldons J. Lusis, Cathy C. Lee, Mark O. Goodarzi, Jerome I. Rotter, Joshua R. Hansen, Ben Drucker, Tyler J. Sagendorf, Joshua N. Adkins, James A. Sanford, Francesco J. DeMayo, Sylvia C. Hewitt, Kenneth S. Korach, Andrea L. Hevener
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-05-01
Series:	Cell Reports Medicine
Assuntos:	estrogen action insulin sensitivity mitochondrial function mtDNA replication mitochondrial cristae architecture oxidative metabolism
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2666379125001892
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