A new stochastic model for subgenomic hepatitis C virus replication considers drug resistant mutants.

As an RNA virus, hepatitis C virus (HCV) is able to rapidly acquire drug resistance, and for this reason the design of effective anti-HCV drugs is a real challenge. The HCV subgenomic replicon-containing cells are widely used for experimental studies of the HCV genome replication mechanisms, for dru...

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Auteurs principaux:	Nikita V Ivanisenko, Elena L Mishchenko, Ilya R Akberdin, Pavel S Demenkov, Vitaly A Likhoshvai, Konstantin N Kozlov, Dmitry I Todorov, Vitaly V Gursky, Maria G Samsonova, Alexander M Samsonov, Diana Clausznitzer, Lars Kaderali, Nikolay A Kolchanov, Vladimir A Ivanisenko
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2014-01-01
Collection:	PLoS ONE
Accès en ligne:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0091502&type=printable
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