Development of Replicon Cell Pools Bearing a Flavivirus RNA Replicon as a Source of HIV-1 Gag-Pol for Lentiviral Vector Production

Lentiviral vectors (LVs) are indispensable tools in cell and gene therapy. Rising demand has created a global shortage of LVs, driving the development of novel packaging approaches. We report a novel vector packaging approach using autonomously replicating cytoplasmic RNAs (replicons) to express pac...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Aitolkyn Kydyrbayeva, Viktoriya Keyer, Tolganay Kulatay, Gulzat Zauatbayeva, Bakytkali Ingirbay, Maral Zhumabekova, Arman Abeev, Gaziza Nigmatulla, Alexandr V. Shustov
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2026-05-01
Serie:	Biology
Ämnen:	lentiviral vectors viral vector manufacturing gene therapy RNA replicons flavivirus replicon yellow fever virus
Länkar:	https://www.mdpi.com/2079-7737/15/11/848
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!