Development of Replicon Cell Pools Bearing a Flavivirus RNA Replicon as a Source of HIV-1 Gag-Pol for Lentiviral Vector Production

Lentiviral vectors (LVs) are indispensable tools in cell and gene therapy. Rising demand has created a global shortage of LVs, driving the development of novel packaging approaches. We report a novel vector packaging approach using autonomously replicating cytoplasmic RNAs (replicons) to express pac...

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主要な著者:	Aitolkyn Kydyrbayeva, Viktoriya Keyer, Tolganay Kulatay, Gulzat Zauatbayeva, Bakytkali Ingirbay, Maral Zhumabekova, Arman Abeev, Gaziza Nigmatulla, Alexandr V. Shustov
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2026-05-01
シリーズ:	Biology
主題:	lentiviral vectors viral vector manufacturing gene therapy RNA replicons flavivirus replicon yellow fever virus
オンライン･アクセス:	https://www.mdpi.com/2079-7737/15/11/848
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