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Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ

Mycobacteria regulate their energy (ATP) levels to sustain their survival even in stringent living conditions. Recent studies have shown that mycobacteria not only slow down their respiratory rate but also block ATP hydrolysis of the F-ATP synthase (α<sub>3</sub>:β<sub>3</sub>:γ:δ:ε:<i>a</i>:<i>b</i...

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Principais autores: Amaravadhi Harikishore, Chui-Fann Wong, Priya Ragunathan, Dennis Litty, Volker Müller, Gerhard Grüber
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-11-01
Serier:Antibiotics
Fag:
tuberculosis
mycobacteria
F-ATP synthase
bioenergetics
inhibitor
pharmacophore
Online adgang:https://www.mdpi.com/2079-6382/10/12/1456
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