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Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ

Mycobacteria regulate their energy (ATP) levels to sustain their survival even in stringent living conditions. Recent studies have shown that mycobacteria not only slow down their respiratory rate but also block ATP hydrolysis of the F-ATP synthase (α<sub>3</sub>:β<sub>3</sub>:γ:δ:ε:<i>a</i>:<i>b</i...

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Hoofdauteurs: Amaravadhi Harikishore, Chui-Fann Wong, Priya Ragunathan, Dennis Litty, Volker Müller, Gerhard Grüber
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2021-11-01
Reeks:Antibiotics
Onderwerpen:
tuberculosis
mycobacteria
F-ATP synthase
bioenergetics
inhibitor
pharmacophore
Online toegang:https://www.mdpi.com/2079-6382/10/12/1456
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