Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/proteasome system (UPS). Previous studies have described an age-de...

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Autors principals:	Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2011-09-01
Col·lecció:	PLoS Genetics
Accés en línia:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002253&type=printable
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