N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells

Chronic inflammation of pancreatic islets is a key driver of β-cell damage that can lead to autoreactivity and the eventual onset of autoimmune diabetes (T1D). In the islet, elevated levels of proinflammatory cytokines induce the transcription of the inducible nitric oxide synthase (iNOS) gene, NOS2...

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Autors principals:	Joshua A. Nord, Sarah L. Wynia-Smith, Alyssa L. Gehant, Rachel A. Jones Lipinski, Aaron Naatz, Inmaculada Rioja, Rab K. Prinjha, John A. Corbett, Brian C. Smith
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2022-09-01
Col·lecció:	Frontiers in Endocrinology
Matèries:	BET bromodomain BRD4 diabetes small molecule inhibitor iNOS nitric oxide
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fendo.2022.923925/full
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