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Novel PLEC-EML4-ALK Double Fusion Underlying Crizotinib Resistance in a Metastatic Inflammatory Myofibroblastic Tumor: A Case Report

ALK fusions are frequent oncogenic drivers in inflammatory myofibroblastic tumors. Treatment with crizotinib is effective in fusion-positive patients; however, acquired resistance remains a challenge. Here, we present a case of EML4-ALK-positive metastatic inflammatory myofibroblastic tumor that ini...

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Principais autores: Alessandra Maleddu, MD, Trista K. Hinz, MS, Margaret A. Black, MD, Dara L. Aisner, MD, PhD, Carrie B. Marshall, MD, Anthony D. Elias, MD, Breelyn A. Wilky, MD, Lynn E. Heasley, PhD, Kurtis D. Davies, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-05-01
Serier:JTO Clinical and Research Reports
Fag:
Case report
ALK fusion
Crizotinib
Inflammatory myofibroblastic tumor
Online adgang:http://www.sciencedirect.com/science/article/pii/S2666364325000074
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