Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

Summary: Although global H3K27me3 reprogramming is a hallmark of cancer, no effective therapeutic strategy for H3K27me3-high malignancies harboring EZH2WT/WT has yet been established. We explore epigenome and transcriptome in EZH2WT/WT and EZH2WT/Mu aggressive lymphomas and show that mutual interfer...

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Główni autorzy:	Makoto Yamagishi, Makoto Hori, Dai Fujikawa, Takeo Ohsugi, Daisuke Honma, Nobuaki Adachi, Harutaka Katano, Tsunekazu Hishima, Seiichiro Kobayashi, Kazumi Nakano, Makoto Nakashima, Masako Iwanaga, Atae Utsunomiya, Yuetsu Tanaka, Seiji Okada, Kunihiro Tsukasaki, Kensei Tobinai, Kazushi Araki, Toshiki Watanabe, Kaoru Uchimaru
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2019-11-01
Seria:	Cell Reports
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S2211124719314056
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